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IMPORTANT! This must-read article helps dog parent quickly and for the long-term support their companion’s joint health, backed by veterinary science.
Joint disorders in dogs are very common yet widely overlooked.
They affect about 38% (almost 4 out of 10!) of adult dogs and as many as 80% of dogs over eight years old.
All breeds can be affected, but some are more predisposed than others—especially larger breeds such as Labradors, German Shepherds, Great Danes, Rottweilers, and Poodles, and even smaller breeds like French Bulldogs and Dachshunds.[1]
Despite dog parents’ best intentions, few cases are detected and treated properly because of limited awareness or the high cost of veterinary visits.
These conditions (joint problems, premature joint wear, injury, or post-surgical after-effects) cause intense discomfort that drastically reduces a dog’s motivation and enthusiasm for life.
It is never too late to support your dog's joint health, but early support can make a real difference.
Thanks to this article written by our veterinarians, every dedicated dog parent will learn how to:
Limited physical capabilities
Visible signs
Behavioural changes(hardest to detect)
Not all signs need to be present to show your dog has joint problems, but if you see any, we always recommend checking with your veterinarian.
Recent clinical study ⇒ Not effective
Low bioavailability
Not effective
Glucosamine + chondroitin is probably the first non-drug option for many pup parents, but all recent studies show the same thing: it doesn’t work. One nutraceutical review even concludes they should not be prescribed for arthritis in dogs and cats. [3]
No clinical study in dogs
Interactions
Digestive issues
While studies have been conducted in vitro, no clinical trials show efficacy in dogs. Human studies show very limited results.
In the last decade, scientists and veterinarians have searched for better options, knowing existing treatments were not good enough and seeing more dogs develop joint problems.
A new natural ingredient from human medicine has been discovered: UC-II® collagen.
Unlike other collagens, UC-II® has a unique mode of action thanks to its 3-D structure—and many studies have been done in dogs!
Placebo-controlled 120-day study (D’Altilio) [4]
Vet-assessed comparison to glucosamine (Canerdy) [5]
Ground-force-plate trial (Gupta) [5]
Healthy-animal study (Varney) [6]
2020 scoping review (Gencoglu) [7]
Long-term study (Cabezas) [8]
Within 30 days, UC-II cut overall discomfort by 33 %; by day 120, lameness dropped 78 %.
While glucosamine + chondroitin showed limited results, UC-II was significantly better and decreased overall pain by 81%.
UC-II dogs showed a significant rise in weight-bearing force and a 42 % drop in pain scores vs. glucosamine + chondroitin = non-significant.
UC-II improves flexibility and limits pain after intense exercise in healthy dogs.
18 human & animal studies reviewed confirm consistent improvements in lameness and activity.
A 6-month study showed continuous improvement.
And many other studies simply show: IT WORKS!
Shown to limit vicious cycle at the joint level in dogs
Shown to support joint health in healthy dogs too, with potential preventive effects
Shown to support cartilage health under the microscope in rats
Shown to reduce joint discomfort in dogs (measured by force-plate and vet assessment)
Shown to deliver long-term benefits for joint health
95% of products on the market are made with glucosamine and chondroitin.
Why?
Because it’s made from shellfish and very cheap (you can buy a full kilogram, 2.2 lb, of pure glucosamine for less than $30).
But…
The reality is that you may hope to see results and interpret every little change as improvement while, in the long term, your dog remains uncomfortable and joint health is not truly supported. Eventually you realize, after two or three months, “it doesn’t work anymore”—when in fact it never worked.
Studies confirm this, like a recent nutraceutical review stating:
Chondroitin–glucosamine nutraceuticals showed strong evidence of non-effect … These results lead to the conclusion that chondroitin–glucosamine nutraceuticals should not be prescribed in canine or feline arthritis.
Or another review analysing only glucosamine studies, concluding:
“Although glucosamine and chondroitin have benign adverse-effect profiles, the clinical benefit of using these agents remains questionable.”
ARE THERE LINKS TO THE STUDIES?
It’s easy to claim “it works,” but evidence must be accessible. Most reputable brands list studies at the bottom of their page e.g., UC-II studies.
IS IT THIRD-PARTY TESTED?
A good ingredient on the label is one thing; having it in the product is another. Always ask for an independent lab test.
ARE VETERINARIANS INVOLVED?
Veterinarians are health experts. A trustworthy formula should have vets, or at least recognised specialists, on the founding team.
ARE THE INGREDIENTS CORRECTLY DOSED?
Some products sprinkle tiny amounts just for marketing. An ingredient proven effective is always tested at a specific dose for a specific dog size.
Example: For UC-II, the research dose is 40 mg for average dogs (20 mg small / 60 mg large).
The story of UC-II begins with Dr. Eugene Moore, a scientist whose 8-year-old daughter Anne-Marie suffered from rheumatoid arthritis. Dr. Moore turned his kitchen into a lab and developed a unique undenatured type-II collagen, which successfully helped his daughter!
The promising research was then tested on dogs (a common step before human studies) and, study after study, UC-II’s potential in dogs was confirmed.
The science behind UC-II now stands alongside EPA & DHA (the “good” omega-3s) as the only ingredients that show positive results on force-plate studies.
Dr. Christine discovered UC-II while combing PubMed for a better solution for her dog Pepsi, who also suffered from arthritis (a story she later learned echoed Dr. Moore’s).
She had tried the usual options listed earlier: NSAIDs (Pepsi had adverse events) and high-dose glucosamine + chondroitin + MSM, none worked.
So she tried UC-II with two more ingredients:
After the first month she noticed subtle changes. The real results arrived after 90 days, exactly as UC-II and EPA & DHA studies suggested:
“I saw a whole different dog: running with me again, climbing stairs, having fun. I found the dog I’d lost months before.”
That journey led to Joy of Pets, Jope, crafted from the same combination of ingredients, right here in the USA.
Jope was developed by Dr. Christine and her close friend Dr. Jeremy, both veterinarians. They went further than just effective ingredients:
Cold-pressed method to preserve vitamins
Omega-3s from small fish to avoid heavy metals
Tasty soft chews dogs love
Formulation with 80 % organic ingredients
Helps maintain healthy cartilage
Supports the immune system to interrupt the vicious cycle inside joints
Supports overall mobility
Favors comfortable and flexible joints
First results may appear after 3 weeks, but you NEED 3 months to fully assess Jope’s benefits! Exactly the timeframe demonstrated in studies.
That doesn’t mean you won’t see further improvement afterward, but 90 days is the minimum for a fair assessment.
And Jope know it!
They offer a 90-day guarantee: if you see no results, simply email for a 100 % refund—no questions asked.
Only 3% of customers ever need it.
Jope reviews prove it works. Thousands of pet parents have switched from glucosamine supplements to Jope with great results. Many were skeptical at first because the brand is relatively new but decided to try because it’s vet-made and guaranteed.
Ordering on petjope.com gives you the best pricing direct from the brand.
How to get the best price:
Every Jope ingredient is rigorously selected. The company requires a Certificate of Origin and Certificate of Analysis for each one, then tests every batch with an independent lab to verify active levels.
This is the ultimate proof you get what you pay for. A human-supplement survey showed most online products did not contain labeled amounts (sometimes the ingredient wasn’t detected at all!).
Manufacturing facility: GMP certified and NASC approved (National Animal Supplement Council).
Manufactured in the USA, Midwest.
Small business owned by veterinarians Dr. Christine and Dr. Jeremy.
Questions? Email contact@petjope.com
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC7198754
[2] “Nonsteroidal Anti‑Inflammatory Drugs in Animals.” MSD Veterinary Manual, Merck & Co., Inc., n.d., https://www.msdvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals.
[3] Barbeau-Grégoire, Maude et al. “A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis.” International journal of molecular sciences vol. 23,18 10384. 8 Sep. 2022, doi:10.3390/ijms231810384 ‘
[4] D'Altilio M, Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad JT, Bagchi M, Bagchi D. Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in Arthritic Dogs. Toxicol Mech Methods. 2007;17(4):189-96. doi: 10.1080/15376510600910469. PMID: 20020968.
[5] Gupta RC, Canerdy TD, Lindley J, Konemann M, Minniear J, Carroll BA, Hendrick C, Goad JT, Rohde K, Doss R, Bagchi M, Bagchi D. Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. J Anim Physiol Anim Nutr (Berl). 2012 Oct;96(5):770-7. doi: 10.1111/j.1439-0396.2011.01166.x. Epub 2011 May 30. PMID: 21623931.
[6] Varney, J L et al. “Undenatured type II collagen mitigates inflammation and cartilage degeneration in healthy Labrador Retrievers during an exercise regimen.” Translational animal science vol. 5,2 txab084. 10 May. 2021, doi:10.1093/tas/txab084
[7] Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals (Basel). 2020 Apr 17;10(4):697. doi: 10.3390/ani10040697. PMID: 32316397; PMCID: PMC7222752.
[8] Cabezas, Miguel Ángel et al. “Long-term supplementation with an undenatured type-II collagen (UC-II®) formulation in dogs with degenerative joint disease: Exploratory study.” Open veterinary journal vol. 12,1 (2022): 91-98. doi:10.5455/OVJ.2022.v12.i1.11
[9] Bagi CM, Berryman ER, Teo S, Lane NE. Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090. doi: 10.1016/j.joca.2017.08.013. Epub 2017 Sep 6. PMID: 28888901.
Jope is a dietary supplement for companion animals and is not a substitute for a balanced diet. Follow the recommendations on petjope.com and the dosages advised. If your pet is on medication or suffers from a medical condition, consult a veterinarian. If your pet shows unusual symptoms while using Jope, contact customer care. If symptoms persist or you are in doubt, stop using the product and consult your veterinarian. This article is an advertorial written by veterinarians at Jope.
